Dr. Kristin Dittenhafer-ReedAssistant Professor of Chemistry
Dr. Kristin Dittenhafer-Reed is an assistant professor in the Department of Chemistry and Biochemistry. She joined the Hope faculty in 2016. Kristin’s main research and teaching focus is biochemistry.
AREAS OF INTEREST
- Understanding mitochondrial function in human health and disease
- Mechanisms of control of mitochondrial DNA transcription
- Characterization of mtDNA nucleoid proteins in genome maintenance and transcriptional regulation
Work in Kristin’s lab combines biochemistry, systems biology and chemistry approaches to study the basic biochemical mechanisms governing mitochondrial function and metabolism to allow for a deeper understanding of these diseases.
While core components of mitochondrial transcription initiation are known, a detailed understanding of transcriptional control is lacking. A goal of the research in the Dittenhafer-Reed lab is to uncover biochemical mechanisms that govern mitochondrial gene expression and mtDNA stability.
To understand the maintenance and gene expression of human mtDNA, the Dittenhafer-Reed lab will use biochemical approaches to analyze nucleoid protein structure, post-translational modification and function.
- Postdoctoral fellow, Center for Cancer and Cell Biology, Van Andel Research Institute, 2014–2016
- Ph.D. biochemistry, University of Wisconsin-Madison, 2014
- B.S. chemistry, Hope College, 2009
HONORS, GRANTS, & AWARDS
- Denton Teaching Award, UW-Madison Integrated Program in Biochemistry, 2014
- National Institutes of Health Biotechnology Training Program Trainee, 2012–2014
- National Science Foundation Graduate Research Fellow, 2009–2012
- “Kinetic and structural analysis of acyl-group selectively provides insight into Sirtuin catalyzed deacylation,” Biochemistry, 54 (19), 2015
- “SIRT3 mediates multi-tissue coupling for metabolic fuel switching,” Cell Metabolism, 21 (4), 2015
- “Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation,” The Journal of Biological Chemistry, 36, 2013
- “Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial acetylome,” Molecular Cell, 49, 2013
- “Sirtuin catalysis and regulation,” The Journal of Biological Chemistry, 287 (51), 2012
- “SIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status,” The Journal of Biological Chemistry, 287 (17), 2012
- “Catalysis and mechanistic insights into sirtuin activation,” ChemBioChem, 12, 2011
- “SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production,” Cell Metabolism, 12, 2010
For a complete list of Dr. Dittenhafer-Reed’s published works, click here.
Outside the College
When Kristin is not working at Hope, she enjoys spending time with her husband and family, traveling, cooking and running.